Proprio’s Groundbreaking Research Demonstrates the Potential for a New Standard of Care in Surgery Using Volumetric Intelligence™


This AI technology will enable intraoperative real-time accurate measurements of progress during spine surgery without radiation – an industry first

SEATTLE, April 17, 2024 - Proprio, the leading AI surgical technology company, presented the findings of its latest cadaveric study last week at the 31st International Meeting on Advanced Spine Techniques (IMAST). The study, titled “Optical-Kinematic Measurement of Spinal Alignment: A Radiation-Free Technique Using Light Field Navigation,” examined the accuracy and efficiency of Volumetric Intelligence (VI) in measuring spinal alignment, comparing it to the traditional method of manual, static measurements, like x-ray. VI is a radiation-free computer vision tracking tool that measures vertebral alignment from live 3D optical data. 

Accurately assessing alignment during surgery is vital for achieving preoperative goals. It enables surgeons to make timely adjustments and reduces the likelihood the patient will experience post-surgery complications or even require revision surgery.1 The successful outcome of this study demonstrated how Proprio’s AI-powered guidance can accurately provide spinal alignment measurements better than current surgeon-driven manual methods.  The first of its kind application of this AI-powered technology into the spinal surgery workflow has the potential to significantly impact current surgical techniques and provide real-time information that may ultimately impact patient outcomes.  

The study included seven experienced spine surgeons who each annotated 28 images, demonstrating that VI provides superior accuracy in measuring spinal alignment during spinal corrective maneuvers compared to traditional manual methods. Results showed that the absolute difference between automated and manual measures was 1.96° (SD=1.30), and 95% of all data were within 2.53° of the mean manual measure. On average, the individual surgeon measures were within 3.38° of their mean (RMSE). This means that Proprio’s VI technology provides intraoperative alignment measurements with less error than spine surgeons’ manual measurements.

"Achieving precise, patient specific alignment is critical for improving surgical outcomes and reducing complications in spinal deformity cases,” said Dr. Sigurd Berven, a globally recognized orthopedic spine surgeon at the University of California San Francisco. “However, intraoperative measurement of alignment has historically been challenging, time-consuming, and involves the use of ionizing radiation. The findings of this study highlight the potential of Proprio’s Volumetric Intelligence™ to improve clinical outcomes by providing real time, intraoperative, actionable data in spine surgery, and serve as an invaluable resource to surgeons throughout the procedure.”

For more information on Proprio’s Volumetric Intelligence technology, visit


Proprio is a leading medical technology company creating a new way of seeing™ in surgery. Using advances in light field computer vision and AI, the Proprio Paradigm system synthesizes views from multiple inputs for navigating anatomy and surgical environments in 3D. Proprio’s goal is to dramatically improve clinical and economic outcomes by unlocking both the ability to capture advanced data and the potential of that data to inform more predictive and prescriptive intelligence in surgery. Proprio is backed by leading healthcare and technology investors, including DCVC, BOLD Capital Partners, Bird B. AG, Intel, HTC, and Alan Frazier, founder of Frazier Healthcare Partners.


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1 Rothenfluh DA, Mueller DA, Rothenfluh E, Min K. Pelvic incidence-lumbar lordosis mismatch predisposes to adjacent segment disease after lumbar spinal fusion. Eur Spine J. 2015;24(6):1251–1258. doi:10.1007/s00586-014-3454-0